Protein Kinase Cα (PKCα) Regulates Bone Architecture and Osteoblast Activity
نویسندگان
چکیده
منابع مشابه
Protein Kinase Cα (PKCα) Regulates Bone Architecture and Osteoblast Activity*
Bones' strength is achieved and maintained through adaptation to load bearing. The role of the protein kinase PKCα in this process has not been previously reported. However, we observed a phenotype in the long bones of Prkca(-/-) female but not male mice, in which bone tissue progressively invades the medullary cavity in the mid-diaphysis. This bone deposition progresses with age and is prevent...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2014
ISSN: 0021-9258
DOI: 10.1074/jbc.m114.580365